Oncogene activation
نویسندگان
چکیده
منابع مشابه
Mechanisms of Oncogene Activation
The main modifications that characterize cancer are represented by alterations in onco‐ genes, tumor-suppressor genes, and non-coding RNA genes. Most of these alterations are somatic and the process is a multistep one. Tumors often arise from an initial trans‐ formed cell, and after subsequent genetic alterations different cytogenetically clones lead to tumor heterogeneity. Oncogenes encode pro...
متن کاملOncogene activation and tumor progression.
25 years ago (1) Leslie Foulds formulated a number of 'rules' for tumor progression, the process whereby 'tumors go from bad to worse', in Peyton Rous' original description (2). These rules are equally pertinent today and accessible to analysis by the powerful tools of modem biology. Foulds dissected the malignant phenotype into 'unit characteristics', such as growth rate, invasiveness, metasta...
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The TCLI oncogene on human chromosome 14q32.1 is involved in chromosome translocations [t(14;14)(qll;q32.1) and t(7;14)(q35;q32.1)1 and inversions [inv14(qll;q32.1)] with TCRaIP loci in T-cell leukemias, such as T-prolymphocytic (T-PLL). It is also involved in T-acute and -chronic leukemias arising in cases of ataxia-telangiectasia (AT), an immunodeficiency syndrome. Similar chromosomal rea...
متن کاملOncogene Activation in Human Myeloid Leukemia1
We have studied by means of DMA-mediated gene transfer the activation of protooncogenes in human myeloid leukemias that represent various stages of myeloid differentiation. DMA from three cell lines, HL-60 (promyelocytic leukemia), Rc2a (myelomonocytic leukemia), and KG-1 (acute myeloblastic leukemia), was capable of transforming NIH/3T3 cells. Hybridization analy sis indicated that, in all thr...
متن کاملRole of proto-oncogene activation in carcinogenesis.
The accumulation of genetic damage in the forms of activated proto-oncogenes and inactivated tumor-suppressor genes is the driving force in the evolution of a normal cell to a malignant cell. For example, both the activation of ras oncogenes and the inactivation of several suppressor genes, including p53, have been observed in the development of human colon and lung tumors. Point mutations in k...
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ژورنال
عنوان ژورنال: Nature
سال: 1982
ISSN: 0028-0836,1476-4687
DOI: 10.1038/300680f0